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Ionizing radiation biomarkers in epidemiological studies –An update

Version 2 2023-06-12, 07:24
Version 1 2023-06-09, 14:34
journal contribution
posted on 2023-06-12, 07:24 authored by Janet Hall, Penny Jeggo, Catherine West, Maria Gomolka, Roeal Quintens, Christophe Badie, Olivier Laurent, An Aerts, Nataša Anastaov, Omid Azimzadehh, Others
Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of <100mSv and dose rates of <10mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30-60mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted. One biomarker identified in the final stages of development and as a priority for further research is radiation specific mRNA transcript profiles.

History

Publication status

  • Published

File Version

  • Published version

Journal

Mutation Research - Reviews

ISSN

1383-5742

Publisher

Elsevier

Volume

771

Page range

59-84

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Research groups affiliated with

  • Genome Damage and Stability Centre Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-08-16

First Open Access (FOA) Date

2018-08-21

First Compliant Deposit (FCD) Date

2018-08-15

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