Technical considerations for the generation of novel pseudotyped viruses

King, Barnabas, Temperton, Nigel J, Grehan, Keith, Scott, Simon D, Wright, Edward, Tarr, Alexander W and Daly, Janet M (2015) Technical considerations for the generation of novel pseudotyped viruses. Future Virology, 11 (1). pp. 47-59. ISSN 1746-0794

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Abstract

A pseudotyped virus (PV) is a virus particle with an envelope protein originating from a different virus. The ability to dictate which envelope proteins are expressed on the surface has made pseudotyping an important tool for basic virological studies such as determining the cellular targets of the envelope protein of the virus as well as identification of potential antiviral compounds and measuring specific antibody responses. In this review, we describe the common methodologies employed to generate PVs, with a focus on approaches to improve the efficacy of PV generation.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QR Microbiology > QR0355 Virology
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Depositing User: Edward Wright
Date Deposited: 14 Aug 2018 09:57
Last Modified: 01 Mar 2019 10:55
URI: http://sro.sussex.ac.uk/id/eprint/77826
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