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Technical considerations for the generation of novel pseudotyped viruses

journal contribution
posted on 2023-06-09, 14:32 authored by Barnabas King, Nigel J Temperton, Keith Grehan, Simon D Scott, Edward WrightEdward Wright, Alexander W Tarr, Janet M Daly
A pseudotyped virus (PV) is a virus particle with an envelope protein originating from a different virus. The ability to dictate which envelope proteins are expressed on the surface has made pseudotyping an important tool for basic virological studies such as determining the cellular targets of the envelope protein of the virus as well as identification of potential antiviral compounds and measuring specific antibody responses. In this review, we describe the common methodologies employed to generate PVs, with a focus on approaches to improve the efficacy of PV generation.

History

Publication status

  • Published

Journal

Future Virology

ISSN

1746-0794

Publisher

Future Medicine

Issue

1

Volume

11

Page range

47-59

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2018-08-14

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