Roshchin, Matvey V, Matlashov, Mikhail E, Jerusalimsky, Victor N, Balaban, Pavel M, Belousov, Vsevolod V, Kemenes, György, Staras, Kevin and Nikitin, Evgeny S (2018) A BK channel–mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing. Science Advances, 4 (7). eaat1357 1-8. ISSN 2375-2548
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Abstract
Action potential shape is a major determinant of synaptic transmission, and mechanisms of spike tuning are
therefore of key functional significance. We demonstrate that synaptic activity itself modulates future spikes in
the same neuron via a rapid feedback pathway. Using Ca2+ imaging and targeted uncaging approaches in layer
5 neocortical pyramidal neurons, we show that the single spike–evoked Ca2+ rise occurring in one proximal bouton
or first node of Ranvier drives a significant sharpening of subsequent action potentials recorded at the soma.
This form of intrinsic modulation, mediated by the activation of large-conductance Ca2+/voltage-dependent
K+ channels (BK channels), acts to maintain high-frequency firing and limit runaway spike broadening during repetitive
firing, preventing an otherwise significant escalation of synaptic transmission. Our findings identify a
novel short-term presynaptic plasticity mechanism that uses the activity history of a bouton or adjacent axonal
site to dynamically tune ongoing signaling properties.
Item Type: | Article |
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Keywords: | synaptic activity, action potential shape, BK channel, feedback pathway, repetitive firing, layer 5 neocortical pyramidal neurons, Ca2+, targeted Ca2+ uncaging, first node of Ranvier, proximal bouton |
Schools and Departments: | School of Life Sciences > Neuroscience |
Research Centres and Groups: | Sussex Neuroscience |
Subjects: | Q Science Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology > QP0361 Nervous system Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology > QP0361 Nervous system > QP0364 Synapses |
Related URLs: | |
Depositing User: | George Kemenes |
Date Deposited: | 13 Aug 2018 10:57 |
Last Modified: | 02 Jul 2019 14:30 |
URI: | http://sro.sussex.ac.uk/id/eprint/77774 |
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