Disruption of neurite morphology parallels MS progression

Spanò, Barbara, Giuletti, Giovanni, Pisani, Valerio, Morreale, Manuela, Tuzzi, Elisa, Nocentini, Ugo, Francia, Ada, Caltagirone, Carlo, Bozzali, Marco and Cercignani, Mara (2018) Disruption of neurite morphology parallels MS progression. Neurology, Neuroimmunology and Neuroinflammation, 5 (6). pp. 1-10. ISSN 2332-7812

[img] PDF - Published Version
Available under License Creative Commons Attribution-NonCommercial No Derivatives.

Download (1MB)

Abstract

Objectives: To apply advanced diffusion MRI methods to the study of normal appearing brain tissue in MS and examine their correlation with measures of clinical disability. Methods: A multi-compartment model of diffusion MRI called neurite orientation dispersion and density imaging (NODDI) was used to study 20 patients with relapsing-remitting (RR-) and 15 with secondary progressive (SP)-MS, and 20 healthy controls. Maps of NODDI were analyzed voxel-wise to assess the presence of abnormalities within the normal appearing brain tissue, and the association with disease severity. Standard diffusion tensor imaging (DTI) parameters were also computed for comparing the two techniques. Results: MS patients showed reduced neurite density and increased orientation dispersion compared to controls in several brain areas (P<0.05), with SPMS patients having more widespread abnormalities. DTI indices were also sensitive to some changes. In addition, SPMS patients showed reduced orientation dispersion in the thalamus and caudate nucleus. These abnormalities were associated with scores of disease severity (P<0.05). The association with the MS functional composite score was higher in SPMS compared to RRMS patients. Conclusions: NODDI and DTI findings are largely overlapping. Nevertheless, NODDI helps to interpret previous findings of increased anisotropy in the thalamus of MS patients, and are consistent with the degeneration of selective axon populations.

Item Type: Article
Keywords: NODDI, neurodegeneration, orientation dispersion, disability, MS transition
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Research Centres and Groups: Sackler Centre for Consciousness Science
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 13 Aug 2018 08:58
Last Modified: 02 Jul 2019 14:05
URI: http://sro.sussex.ac.uk/id/eprint/77747

View download statistics for this item

📧 Request an update