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Disruption of neurite morphology parallels MS progression

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posted on 2023-06-09, 14:29 authored by Barbara Spanò, Giovanni Giuletti, Valerio Pisani, Manuela Morreale, Elisa Tuzzi, Ugo Nocentini, Ada Francia, Carlo Caltagirone, Marco Bozzali, Mara Cercignani
Objectives: To apply advanced diffusion MRI methods to the study of normal appearing brain tissue in MS and examine their correlation with measures of clinical disability. Methods: A multi-compartment model of diffusion MRI called neurite orientation dispersion and density imaging (NODDI) was used to study 20 patients with relapsing-remitting (RR-) and 15 with secondary progressive (SP)-MS, and 20 healthy controls. Maps of NODDI were analyzed voxel-wise to assess the presence of abnormalities within the normal appearing brain tissue, and the association with disease severity. Standard diffusion tensor imaging (DTI) parameters were also computed for comparing the two techniques. Results: MS patients showed reduced neurite density and increased orientation dispersion compared to controls in several brain areas (P<0.05), with SPMS patients having more widespread abnormalities. DTI indices were also sensitive to some changes. In addition, SPMS patients showed reduced orientation dispersion in the thalamus and caudate nucleus. These abnormalities were associated with scores of disease severity (P<0.05). The association with the MS functional composite score was higher in SPMS compared to RRMS patients. Conclusions: NODDI and DTI findings are largely overlapping. Nevertheless, NODDI helps to interpret previous findings of increased anisotropy in the thalamus of MS patients, and are consistent with the degeneration of selective axon populations.

History

Publication status

  • Published

File Version

  • Published version

Journal

Neurology, Neuroimmunology and Neuroinflammation

ISSN

2332-7812

Publisher

Lippincott,Williams & Wilkins

Issue

6

Volume

5

Page range

1-10

Department affiliated with

  • BSMS Neuroscience Publications

Research groups affiliated with

  • Sackler Centre for Consciousness Science Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-08-13

First Open Access (FOA) Date

2018-08-29

First Compliant Deposit (FCD) Date

2018-08-13

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