Variation at the TRIM11 locus modifies Progressive Supranuclear Palsy phenotype

Jabbari, Edwin, Woodside, John, Tan, Manueal M X, Shoai, Maryam, Pittman, Alan, Ferrari, Raffaele, Mok, Kin Y, Zhang, David, Reynolds, Regina H, de Silva, Rohan, Grimm, Max-Joseph, Respondek, Gesine, Müller, Ulrich, Al-Sarraj, Safa, Gentleman, Stephen M, Lees, Andrew J, Warner, Thomas T, Hardy, John, Revesz, Tamas, Höglinger, Günter U, Holton, Janice L, Ryten, Mina, Morris, Huw R, Leigh, P Nigel and PROSPECT-UK consortium, (2019) Variation at the TRIM11 locus modifies Progressive Supranuclear Palsy phenotype. Annals of neurology, 84 (4). pp. 485-496. ISSN 1531-8249

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Abstract

OBJECTIVE

The basis for clinical variation related to underlying Progressive Supranuclear Palsy (PSP) pathology is unknown. We performed a genome wide association study (GWAS) to identify genetic determinants of PSP phenotype.

METHODS

Two independent pathological and clinically diagnosed PSP cohorts were genotyped and phenotyped to create Richardson's syndrome (RS) and non-RS groups. We carried out separate logistic regression GWAS to compare RS and non-RS groups and then combined datasets to carry out a whole cohort analysis (RS=367, non-RS=130). We validated our findings in a third cohort by referring to data from 100 deeply phenotyped cases from a recent GWAS. We assessed the expression/co-expression patterns of our identified genes and used our data to carry out gene-based association testing.

RESULTS

Our lead single nucleotide polymorphism (SNP), rs564309, showed an association signal in both cohorts, reaching genome wide significance in our whole cohort analysis - OR 5.5 (3.2-10.0), p-value 1.7x10 . rs564309 is an intronic variant of the tripartite motif-containing protein 11 (TRIM11) gene, a component of the ubiquitin proteasome system (UPS). In our third cohort, minor allele frequencies of surrogate SNPs in high linkage disequilibrium with rs564309 replicated our findings. Gene based association testing confirmed an association signal at TRIM11. We found that TRIM11 is predominantly expressed neuronally, in the cerebellum and basal ganglia.

INTERPRETATION

Our study suggests that the TRIM11 locus is a genetic modifier of PSP phenotype and potentially adds further evidence for the UPS having a key role in tau pathology, therefore representing a target for disease modifying therapies. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: Prof Nigel Leigh contributed to this research output as part of the PROSPECT-UK consortium
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 08 Aug 2018 12:29
Last Modified: 31 Jul 2019 01:00
URI: http://sro.sussex.ac.uk/id/eprint/77646

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