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A genetic variant in CDKN2A/2B locus was associated with poor prognosis in patients with 1 esophageal squamous cell carcinoma
journal contribution
posted on 2023-06-09, 14:25 authored by Niloofar Ghobadi, Mehrane Mehramiz, Soodabeh ShahidSales, Arezou Rezaei Brojerdi, Kazem Anvari, Majid Khazaei, Majid Rezayi, Mohammad Sadegh Khorrami, Mona Joudi-Mashhad, Hassan Ramshini, Saeideh Ahmadi-Simab, Ali Moradi, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Mohammad Taher Boroushaki, Gordon FernsGordon Ferns, Amir AvanEsophageal squamous cell carcinoma (ESCC) is among the leading causes of cancer related death. Despite extensive efforts in identifying valid cancer prognostic biomarkers, only a very small number of markers have been identified. Several genetic variants in the 9p21 region have been identified that are associated with the risk of multiple cancers. Here, we explored the association of two genetic variants in the 9p21 region, CDKN2A/B, rs10811661 and rs1333049 for the first time in 273 subjects with, or without ESCC. We observed that patients with ESCC had a higher frequency of a TT genotype for rs10811661 than individuals in the control group, and this polymorphism was also associated with tumor size. Moreover, a CC genotype for the rs1333049 polymorphism was associated with a reduced OS of patients with ESCC. In particular, patients with a CC (rs1333049) genotype had a significantly shorter OS (CC genotype: 34.5±8.9 months vs. CG+GG: 47.7±5.9 months; p value= 0.03). We have also shown the association of a novel genetic variant in CDKN2B gene with clinical outcome of ESCC patients. Further investigations are warranted in a larger population to explore the value of emerging markers as a risk stratification marker in ESCC. Key word: Esophageal squamous cell carcinoma, risk marker, CDKN2A/B, polymorphism
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Cellular PhysiologyISSN
0021-9541Publisher
WileyExternal DOI
Issue
4Volume
234Page range
5070-5076Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-08-08First Open Access (FOA) Date
2019-09-21First Compliant Deposit (FCD) Date
2018-08-07Usage metrics
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