Computational approaches to identify genetic interactions for cancer therapeutics

Benstead-Hume, Graeme, Wooller, Sarah and Pearl, Frances M G (2017) Computational approaches to identify genetic interactions for cancer therapeutics. Journal of Intergrative Bioinformatics, 14 (3). pp. 1-12. ISSN 1613-4516

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The development of improved cancer therapies is frequently cited as an urgent unmet medical need. Here we describe how genetic interactions are being therapeutically exploited to identify novel targeted treatments for cancer. We discuss the current methodologies that use ‘omics data to identify genetic interactions, in particular focusing on synthetic sickness lethality (SSL) and synthetic dosage lethality (SDL). We describe the experimen- tal and computational approaches undertaken both in humans and model organisms to identify these interac- tions. Finally we discuss some of the identified targets with licensed drugs, inhibitors in clinical trials or with compounds under development.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
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Depositing User: Frances Pearl
Date Deposited: 07 Aug 2018 15:44
Last Modified: 02 Jul 2019 15:01

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