accepted Pharmacogenetics of anticancer drug sensitivity and toxicity in colorectal cancer.pdf (1.15 MB)
Pharmacogenetics of anticancer drug sensitivity and toxicity in colorectal cancer
journal contribution
posted on 2023-06-09, 14:22 authored by Reyhaneh Moradi-Marjaneh, Majid Khazaei, Sima Seifi, Seyed Mahdi Hassanian, Gordon FernsGordon Ferns, Amir AvanInter-individual differences in drug response are an important cause of failure in anticancer treatment and adverse drug events in cancer patients. Gene polymorphisms related to these outcomes have been investigated in an effort to find new genetic biomarkers to predict toxicity and response to anticancer drugs. Evaluating the value single nucleotide polymorphisms (SNPs) in the genes involved in transportation, activation and metabolism of anticancer drugs provides a promising approach to select the appropriate therapeutic regimes with at least adverse reactions. This review summarizes the current knowledge about the relationship between of SNPs involved in the transportation, activation and metabolism of anticancer drugs and treatment outcomes in colorectal cancer (CRC) patients.
History
Publication status
- Published
File Version
- Accepted version
Journal
Current Pharmaceutical DesignISSN
1381-6128Publisher
Bentham Science PublishersIssue
23Volume
24Page range
2710-2718Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-08-06First Open Access (FOA) Date
2019-10-24First Compliant Deposit (FCD) Date
2018-08-03Usage metrics
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