University of Sussex
Browse
accepted Pharmacogenetics of anticancer drug sensitivity and toxicity in colorectal cancer.pdf (1.15 MB)

Pharmacogenetics of anticancer drug sensitivity and toxicity in colorectal cancer

Download (1.15 MB)
journal contribution
posted on 2023-06-09, 14:22 authored by Reyhaneh Moradi-Marjaneh, Majid Khazaei, Sima Seifi, Seyed Mahdi Hassanian, Gordon FernsGordon Ferns, Amir Avan
Inter-individual differences in drug response are an important cause of failure in anticancer treatment and adverse drug events in cancer patients. Gene polymorphisms related to these outcomes have been investigated in an effort to find new genetic biomarkers to predict toxicity and response to anticancer drugs. Evaluating the value single nucleotide polymorphisms (SNPs) in the genes involved in transportation, activation and metabolism of anticancer drugs provides a promising approach to select the appropriate therapeutic regimes with at least adverse reactions. This review summarizes the current knowledge about the relationship between of SNPs involved in the transportation, activation and metabolism of anticancer drugs and treatment outcomes in colorectal cancer (CRC) patients.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Current Pharmaceutical Design

ISSN

1381-6128

Publisher

Bentham Science Publishers

Issue

23

Volume

24

Page range

2710-2718

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-08-06

First Open Access (FOA) Date

2019-10-24

First Compliant Deposit (FCD) Date

2018-08-03

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC