The potential therapeutic use of renin-angiotensin system inhibitors in the treatment of inflammatory diseases

Ranjbar, Reza, Shafiee, Mojtaba, Hesari, AmirReza, Ferns, Gordon A, Ghasemi, Faezeh and Avan, Amir (2019) The potential therapeutic use of renin-angiotensin system inhibitors in the treatment of inflammatory diseases. Journal of Cellular Physiology, 234 (3). pp. 2277-2295. ISSN 0021-9541

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Abstract

Inflammation is a normal part of the immune response to injury or infection but its dysregulation promotes the development of inflammatory diseases, which cause considerable human suffering. Non-steroidal anti-inflammatory agents (NSAIDs) are the most commonly prescribed agents for the treatment of inflammatory diseases but they are accompanied by a broad range of side effects, including gastrointestinal and cardiovascular events. The renin-angiotensin system (RAS) is traditionally known for its role in blood pressure regulation. However, there is increasing evidence that RAS signalling is also involved in the inflammatory response associated with several disease states. Angiotensin II increases blood pressure by binding to angiotensin type 1 (AT1) receptor, and direct renin inhibitors (DRIs), angiotensin-converting enzyme (ACE) inhibitors and AT1 receptor blockers (ARBs) are clinically used as anti-hypertensive agents. Recent data suggest that these drugs also have anti-inflammatory effects. Therefore, this review summarizes these recent findings for the efficacy of two of the most widely used antihypertensive drug classes, ACE inhibitors and ARBs, to reduce or treat inflammatory diseases such as atherosclerosis, arthritis, steatohepatitis, colitis, pancreatitis and nephritis.

Item Type: Article
Keywords: Renin-angiotensin system; angiotensin-converting enzyme inhibitors; angiotensin receptor blockers; inflammatory diseases
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Elizabeth Renvoize
Date Deposited: 20 Jul 2018 13:24
Last Modified: 07 Sep 2019 01:00
URI: http://sro.sussex.ac.uk/id/eprint/77293

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