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The potential therapeutic use of renin-angiotensin system inhibitors in the treatment of inflammatory diseases
journal contribution
posted on 2023-06-09, 14:13 authored by Reza Ranjbar, Mojtaba Shafiee, AmirReza Hesari, Gordon FernsGordon Ferns, Faezeh Ghasemi, Amir AvanInflammation is a normal part of the immune response to injury or infection but its dysregulation promotes the development of inflammatory diseases, which cause considerable human suffering. Non-steroidal anti-inflammatory agents (NSAIDs) are the most commonly prescribed agents for the treatment of inflammatory diseases but they are accompanied by a broad range of side effects, including gastrointestinal and cardiovascular events. The renin-angiotensin system (RAS) is traditionally known for its role in blood pressure regulation. However, there is increasing evidence that RAS signalling is also involved in the inflammatory response associated with several disease states. Angiotensin II increases blood pressure by binding to angiotensin type 1 (AT1) receptor, and direct renin inhibitors (DRIs), angiotensin-converting enzyme (ACE) inhibitors and AT1 receptor blockers (ARBs) are clinically used as anti-hypertensive agents. Recent data suggest that these drugs also have anti-inflammatory effects. Therefore, this review summarizes these recent findings for the efficacy of two of the most widely used antihypertensive drug classes, ACE inhibitors and ARBs, to reduce or treat inflammatory diseases such as atherosclerosis, arthritis, steatohepatitis, colitis, pancreatitis and nephritis.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Cellular PhysiologyISSN
0021-9541Publisher
WileyExternal DOI
Issue
3Volume
234Page range
2277-2295Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-07-20First Open Access (FOA) Date
2019-09-07First Compliant Deposit (FCD) Date
2018-07-20Usage metrics
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