The potential prognostic and therapeutic application of tissue and circulating microRNAs in cervical cancer

Hasanzadeh, Malihe, Movahedi, Mehraneh, Rejali, Marzieh, Maleki, Faezeh, Moetamani-Ahmadi, Mehrdad, Seifi, Sima, Hosseini, Zeinab, Khazaei, Majid, Amerizadeh, Forouzan, Ferns, Gordon A, Rezayi, Majid and Avan, Amir (2019) The potential prognostic and therapeutic application of tissue and circulating microRNAs in cervical cancer. Journal of Cellular Physiology, 234 (2). pp. 1289-1294. ISSN 0021-9541

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Abstract

Cervical cancer (CC) is a common malignancy in women and a major cause of cancer- related mortality globally. Some novel biomarkers may enable the early diagnosis and monitoring of CC. MicroRNAs are small noncoding RNAs that control gene translation at a post transcriptional level. Hence the deregulation of these molecules can cause many diseases. There appears to be an association between aberrant miRNA expression and CC, but the molecular mechanisms involved in the development of CC remain unknown. The upregulation of some circulating miRNAs, e.g. miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue specific-miRNAs, e.g. miR-7, miR-10a, miR-17-5p, miR-135b, miR-149 and miR-203 has been found in patients with CC. There is also growing evidence for the importance of miRNAs in the development of drug-resistance. This review therefore highlights recently published preclinical and clinical investigation performed on tissue-specific and circulating miRNAs, as potential biomarkers for the detection of patients at early stages of CC, in the prediction of prognosis, and monitoring of their response to therapy.
Key word: cervical cancer, CIN, MiRNA, circulating biomarker, tissue-specific biomarker, HPV

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Elizabeth Renvoize
Date Deposited: 20 Jul 2018 12:05
Last Modified: 07 Sep 2019 01:00
URI: http://sro.sussex.ac.uk/id/eprint/77288

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