The neurobiology of interoception in health and disease

Quadt, Lisa, Critchley, Hugo D and Garfinkel, Sarah N (2018) The neurobiology of interoception in health and disease. Annals of the New York Academy of Sciences, 1428 (1). pp. 112-128. ISSN 0077-8923

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Abstract

Interoception is the sensing of internal bodily sensations. Interoception is an umbrella term that encompasses (1) the afferent (body‐to‐brain) signaling through distinct neural and humoral (including immune and endocrine) channels; (2) the neural encoding, representation, and integration of this information concerning internal bodily state; (3) the influence of such information on other perceptions, cognitions, and behaviors; (4) and the psychological expression of these representations as consciously accessible physical sensations and feelings. Interoceptive mechanisms ensure physiological health through the cerebral coordination of homeostatic reflexes and allostatic responses that include motivational behaviors and associated affective and emotional feelings. Furthermore, the conscious, unitary sense of self in time and space may be grounded in the primacy and lifelong continuity of interoception. Body‐to‐brain interactions influence physical and mental well‐being. Consequently, we show that systematic investigation of how individual differences, and within‐individual changes, in interoceptive processing can contribute to the mechanistic understanding of physical and psychological disorders. We present a neurobiological overview of interoception and describe how interoceptive impairments at different levels relate to specific physical and mental health conditions, including sickness behaviors and fatigue, depression, eating disorders, autism, and anxiety. We frame these findings in an interoceptive predictive processing framework and highlight potential new avenues for treatments.

Item Type: Article
Keywords: interoception, health, mental health, predictive processing, autism, anxiety, depression, eating disorders
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Research Centres and Groups: Sackler Centre for Consciousness Science
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0438 Psychiatry
Depositing User: Alexei Fisk
Date Deposited: 18 Jul 2018 15:34
Last Modified: 17 Oct 2018 16:03
URI: http://sro.sussex.ac.uk/id/eprint/77267

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