The prognostic value of long noncoding RNA MEG3 expression in the survival of cancer patients: a meta-analysis

Binabaj, Maryam Moradi, Bahrami, Afsane, Bahreyni, Amirhossein, Shafiee, Mojtaba, Rahmani, Farzad, Khazaei, Majid, Soleimanpour, Saman, Ghorbani, Elnaz, Fiuji, Hamid, Ferns, Gordon A, Ryzhikov, Mikhail, Avan, Amir and Hassanian, Seyed Mahdi (2018) The prognostic value of long noncoding RNA MEG3 expression in the survival of cancer patients: a meta-analysis. Journal of Cellular Biochemistry, 119 (11). pp. 9583-9590. ISSN 0730-2312

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Abstract

Long non-coding RNAs (lncRNAs) play an important role in carcinogenesis and cancer progression. lncRNA MEG3 is a tumor suppressor that is down-regulated in several cancers. However, its prognostic value in human malignancies remains controversial. We have therefore undertaken a meta-analysis to explore the relationship between cancer survival and the expression of long non-coding RNA MEG3. A systematic literature search identified 13 potentially eligible investigations comprising 1733 patients in nine different cancer types. In the pooled analysis, a low expression of MEG3 was associated with a low overall survival (OS) in cancer patients with a combined HR of 0.830 [hazard ratio (HR) =0.83; 95% CI: 0.70–0.98; P=0.0.03; random effect model]. However, sub-group analysis according to cancer type revealed that MEG3 expression was not associated with better OS in gastrointestinal cancer (HR = 0.58, 95% CI = 0.33 to 1.03, P = 0.06) and breast cancer patients (HR = 0.85, 95% CI: 0.12 to 5.88, P = 0.87). In conclusion, our results demonstrate that only in the pooled analysis, there was a significant relationship between MEG3 expression and cancer survival. Further investigation of other molecular biomarkers involved in tumorigenesis-related pathways is necessary.

Item Type: Article
Keywords: LncRNAs, Maternally expressed gene 3, Tumor survival
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Gordon Ferns
Date Deposited: 27 Jun 2018 10:11
Last Modified: 20 Aug 2019 01:00
URI: http://sro.sussex.ac.uk/id/eprint/76750

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