Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: potential application for pancreatic cancer tissue engineering

Matt-Domjan, Brigitta, King, Alice, Totti, Stella, Matta, Csaba, Dover, George, Martinez, Patrica, Zakhidov, Anvar, La Ragione, Roberto, Macedo, Hugo, Jurewicz, Izabela, Dalton, Alan and Velliou, Eirini (2017) Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: potential application for pancreatic cancer tissue engineering. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106 (5). pp. 1637-1644. ISSN 1552-4973

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Abstract

Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi‐walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds—which are easily tuneable to form sheets/fibers—support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Physics and Astronomy
Research Centres and Groups: Materials Physics Group
Subjects: Q Science > QC Physics
Depositing User: Alice King
Date Deposited: 22 Jun 2018 13:42
Last Modified: 02 Jul 2019 15:22
URI: http://sro.sussex.ac.uk/id/eprint/76680

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