Macdougall, Claire E, Wood, Elizabeth G, Loschko, Jakob, Scagliotti, Valeria, Cassidy, Féaron C, Robinson, Mark E, Feldhahn, Niklas, Castellano, Leandro, Voisin, Mathieu-Benoit, Marelli-Berg, Federica, Gaston-Massuet, Carles, Charalambous, Marika and Longhi, M Paula (2018) Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets. Cell metabolism, 27 (3). 588-601.e4. ISSN 1932-7420

PDF - Published Version Available under License Creative Commons Attribution. Download (3MB)

Abstract

Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/β-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPARγ pathway in cDC2 DCs directly suppresses their activation. Combined, they promote an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance. Under long-term over-nutrition, changes in adipocyte biology curtail β-catenin and PPARγ activation, contributing to VAT inflammation.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Biochemistry
Depositing User:	Leandro Castellano
Date Deposited:	15 Jun 2018 08:44
Last Modified:	02 Jul 2019 15:31
URI:	http://sro.sussex.ac.uk/id/eprint/76516

View download statistics for this item

📧 Request an update