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Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets
journal contribution
posted on 2023-06-09, 13:46 authored by Claire E Macdougall, Elizabeth G Wood, Jakob Loschko, Valeria Scagliotti, Féaron C Cassidy, Mark E Robinson, Niklas Feldhahn, Leandro CastellanoLeandro Castellano, Mathieu-Benoit Voisin, Federica Marelli-Berg, Carles Gaston-Massuet, Marika Charalambous, M Paula LonghiVisceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/ß-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPAR? pathway in cDC2 DCs directly suppresses their activation. Combined, they promote an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance. Under long-term over-nutrition, changes in adipocyte biology curtail ß-catenin and PPAR? activation, contributing to VAT inflammation.
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Publication status
- Published
File Version
- Published version
Journal
Cell MetabolismISSN
1550-4131Publisher
Cell PressExternal DOI
Issue
3Volume
27Page range
588-601.e4Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-06-15First Open Access (FOA) Date
2018-06-15First Compliant Deposit (FCD) Date
2018-06-15Usage metrics
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