Waddell, Simon J and Butcher, Philip D (2009) Intracellular microbe whole-genome expression profiling: methodological considerations and biological inferences. In: Ulrich, E Schaible and Haas, Albert (eds.) Intracellular Niches of Microbes– A Pathogen's Guide through the Host Cell. Wiley-VCH Publishers. ISBN 9783527322077

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Abstract

Understanding the mechanisms by which microbes survive in their host intracellular environments is an essential precursor to developing novel intervention strategies that might exploit the interplay between host and microbe. Transcriptional profiling allows us a glimpse of these molecular interactions and promises to reveal much of this dialogue in both pathogenic and symbiotic settings. Such studies will underpin the development of antivirulence strategies for new therapeutics. This chapter aims to describe the challenges of studying microbial RNA expression from intracellular and in vivo scenarios, and to detail a fraction of the insights acquired from this rapidly expanding field, driven by the recent availability of microbe whole-genome sequence information.

Item Type:	Book Section
Schools and Departments:	Brighton and Sussex Medical School > Global Health and Infection
Subjects:	Q Science > Q Science (General) Q Science > QR Microbiology > QR0075 Bacteria Q Science > QR Microbiology > QR0171 Microorganisms in the animal body Q Science > QR Microbiology > QR0180 Immunology
Depositing User:	Simon Waddell
Date Deposited:	08 May 2012 10:36
Last Modified:	14 Mar 2019 17:00
URI:	http://sro.sussex.ac.uk/id/eprint/7651

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