Reprogramming the Mycobacterium tuberculosis transcriptome during pathogenesis

Waddell, Simon J. (2010) Reprogramming the Mycobacterium tuberculosis transcriptome during pathogenesis. Drug Discovery Today: Disease Mechanisms, 7 (1). e67-e73. ISSN 17406765

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Transcriptional profiling has revealed that Mycobacterium tuberculosis adapts both its metabolic and respiratory states during infection, utilising lipids as a carbon source and switching to alternative electron acceptors. These global gene expression datasets may be exploited to identify virulence determinants and to screen for new targets for rational drug design. Characterising the changing physiological predicament of distinct M. tb populations during infection will help expose the fundamental biology of M. tb highlighting mechanisms that influence tuberculosis pathogenicity.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology > QR0075 Bacteria
Q Science > QR Microbiology > QR0171 Microorganisms in the animal body
Depositing User: Simon Waddell
Date Deposited: 09 May 2012 08:53
Last Modified: 02 Jul 2019 18:04

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