s13346-018-0519-3.pdf (9.63 MB)
Chemico-calorimetric analysis of amorphous granules manufactured via continuous granulation process
journal contribution
posted on 2023-06-20, 14:17 authored by Mridul Majumder, Saeid Rajabnezhad, Ali Nokhodchi, Mohammed ManiruzzamanThe current study explores the first case of the implementation of solution calorimetry (SolCal) in order to determine the amorphous content of crystalline benzoyl-methoxy-methylindol-acetic acid (BMA)—a model poorly soluble drug, in the amorphous granules prepared via single-step continuous twin-screw dry granulations (TSG). Amorphous magnesium aluminometasilicate (Neusilin®) (US2) was used as a novel inorganic carrier via a TwinLab 10 mm twin-screw extruder. The BMA/US2 blends were processed at 180 °C and varying drug: carrier ratios of 1:4, 1:2.5 and 1:1 (w/w). Physico-chemical characterisation conducted via SEM, DSC and XRPD showed amorphous state of the drug in all granulated formulations. Reverse optical microscopy revealed a meso-porous structure of US2 in which the drug particles are adsorbed and/or entrapped within the porous network of the carrier. This phenomenon can be the underlying reason for the increase of the amorphous content in the extruded granules. Solution calorimetry (SolCal) study revealed amorphous content of the drug in all formulations quite precisely, whereas the dynamic vapour sorption (DVS) analysis complemented the results from SolCal. Furthermore, an attempt has been made for the first time to interrelate the findings from the SolCal to that of the release of the drug from the amorphous granules. It can be concluded that SolCal can be used as a novel technique to precisely quantify and interrelate the amorphous content to its physico-chemical performances such as drug release from the granulated formulations processed via TSG
History
Publication status
- Published
File Version
- Published version
Journal
Drug Delivery and Translational ResearchISSN
2190-393XPublisher
Springer VerlagExternal DOI
Issue
6Volume
8Page range
1658-1669Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-06-14First Open Access (FOA) Date
2018-06-14First Compliant Deposit (FCD) Date
2018-06-14Usage metrics
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