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Enhanced optics for time-resolved singlet oxygen luminescence detection
Version 2 2023-06-12, 07:22
Version 1 2023-06-09, 13:35
journal contribution
posted on 2023-06-12, 07:22 authored by Konstantinos Tsimvrakidis, Nathan R Gemmell, Kleanthis Erotokritou, Shigehito Miki, Masahiro Yabuno, Taro Yamashita, Hirotaka Terai, Robert HadfieldSinglet oxygen luminescence dosimetry (SOLD) is a highly promising direct monitoring method for photodynamic therapy (PDT) in the treatment of cancer. Early SOLD systems have been hampered by inefficient excitation, poor optical collection and immature infrared single photon detection technology. We report carefully engineered improvements addressing all of these deficiencies. We use a supercontinuum source with a tunable filter to precisely target the peak absorption wavelength of the chosen photosensitizer; we have designed a compact and versatile optical package for precise alignment; we have successfully employed state-of-the-art superconducting photon counting technologies. Through these improvements, we can achieve real-time histogram acquisition from a photosensitizer in solution test sample. This setup opens the pathway to physiological SOLD studies for PDT dosimetry.
History
Publication status
- Published
File Version
- Published version
Journal
IEEE Journal of Selected Topics in Quantum ElectronicsISSN
1077-260XPublisher
Institute of Electrical and Electronics EngineersExternal DOI
Issue
1Volume
25Page range
1-7Department affiliated with
- Engineering and Design Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-05-31First Open Access (FOA) Date
2018-06-01First Compliant Deposit (FCD) Date
2018-06-01Usage metrics
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