Enhanced optics for time-resolved singlet oxygen luminescence detection

Tsimvrakidis, Konstantinos, Gemmell, Nathan R, Erotokritou, Kleanthis, Miki, Shigehito, Yabuno, Masahiro, Yamashita, Taro, Terai, Hirotaka and Hadfield, Robert (2019) Enhanced optics for time-resolved singlet oxygen luminescence detection. IEEE Journal of Selected Topics in Quantum Electronics, 25 (1). pp. 1-7. ISSN 1077-260X

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)
[img] PDF (© © 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes) - Accepted Version
Available under License All Rights Reserved.

Download (1MB)

Abstract

Singlet oxygen luminescence dosimetry (SOLD) is a highly promising direct monitoring method for photodynamic therapy (PDT) in the treatment of cancer. Early SOLD systems have been hampered by inefficient excitation, poor optical collection and immature infrared single photon detection technology. We report carefully engineered improvements addressing all of these deficiencies. We use a supercontinuum source with a tunable filter to precisely target the peak absorption wavelength of the chosen photosensitizer; we have designed a compact and versatile optical package for precise alignment; we have successfully employed state-of-the-art superconducting photon counting technologies. Through these improvements, we can achieve real-time histogram acquisition from a photosensitizer in solution test sample. This setup opens the pathway to physiological SOLD studies for PDT dosimetry.

Item Type: Article
Schools and Departments: School of Engineering and Informatics > Engineering and Design
Subjects: Q Science > QC Physics > QC0350 Optics. Light
Depositing User: Nathan Gemmell
Date Deposited: 31 May 2018 09:30
Last Modified: 12 Jul 2019 16:01
URI: http://sro.sussex.ac.uk/id/eprint/76248

View download statistics for this item

📧 Request an update