A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system

Kessel, David H, Hasan, Tayyaba, Kim, Michele M, Penjweini, Rozhin, Gemmell, Nathan R, Veilleux, Israel, McCarthy, Aongus, Buller, Gerald, Hadfield, Robert H, Wilson, Brian C and Zhu, Timothy C (2016) A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system. Published in: Proceedings of SPIE: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV. 9694 969406. Society of Photo-optical Instrumentation Engineers ISSN 0277-786X, ISBN 9781628419283

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Abstract

An explicit dosimetry model has been developed to calculate the apparent reacted 1O2 concentration ([1O2]rx) in an in-vivo model. In the model, a macroscopic quantity, g, is introduced to account for oxygen perfusion to the medium during PDT. In this study, the SOED model is extended for PDT treatment in phantom conditions where vasculature is not present; the oxygen perfusion is achieved through the air-phantom interface instead. The solution of the SOED model is obtained by solving the coupled photochemical rate equations incorporating oxygen perfusion through the air-liquid interface. Experiments were performed for two photosensitizers (PS), Rose Bengal (RB) and Photofrin, in solution, using SOED and SOLD measurements to determine both the instantaneous [1O2] as well as cumulative [1O2]rx concentrations, where [1O2=(1/τ▵)•∫[1O2]dt. The PS concentrations varied between 10 and 100 mM for RB and ~200 mM for Photofrin. The resulting magnitudes of [1O2] were compared between SOED and SOLD.

Item Type: Conference Proceedings
Schools and Departments: School of Engineering and Informatics > Engineering and Design
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM0695 Physical medicine. Physical therapy Including massage, exercise, occupational therapy, hydrotherapy, phototherapy, radiotherapy, thermotherapy, electrotherapy
Depositing User: Nathan Gemmell
Date Deposited: 31 May 2018 09:42
Last Modified: 31 May 2018 09:42
URI: http://sro.sussex.ac.uk/id/eprint/76244
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