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A compact fiber-optic probe-based singlet oxygen luminescence detection system

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posted on 2023-06-09, 13:34 authored by Nathan Gemmell, Aongus McCarthy, Michele M Kim, Israel Veilleux, Timothy C Zhu, Gerald S Buller, Brian C Wilson, Robert H Hadfield
This paper presents a novel compact fiberoptic basedsinglet oxygen near-infrared luminescence probe coupledto an InGaAs/InP single photon avalanche diode (SPAD)detector. Patterned time gating of the single-photon de-tector is used to limit unwanted dark counts and eliminatethe strong photosensitizer luminescence background.Singlet oxygen luminescence detection at 1270 nm is con-firmed through spectral filtering and lifetime fitting forRose Bengal in water, and Photofrin in methanol as mod-el photosensitizers. The overall performance, measuredby the signal-to-noise ratio, improves by a factor of 50over a previous system that used a fiberoptic-coupledsuperconducting nanowire single-photon detector. Theeffect of adding light scattering to the photosensitizer isalso examined as a first step towards applications in tissuein vivo.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Biophotonics

ISSN

1864063X

Publisher

Wiley-VCH Verlag

Issue

2

Volume

10

Page range

320-326

Department affiliated with

  • Engineering and Design Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-05-30

First Open Access (FOA) Date

2018-05-31

First Compliant Deposit (FCD) Date

2018-05-31

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