s41416-018-0118-6.pdf (1.14 MB)
A compact fiber-optic probe-based singlet oxygen luminescence detection system
journal contribution
posted on 2023-06-09, 13:34 authored by Nathan Gemmell, Aongus McCarthy, Michele M Kim, Israel Veilleux, Timothy C Zhu, Gerald S Buller, Brian C Wilson, Robert H HadfieldThis paper presents a novel compact fiberoptic basedsinglet oxygen near-infrared luminescence probe coupledto an InGaAs/InP single photon avalanche diode (SPAD)detector. Patterned time gating of the single-photon de-tector is used to limit unwanted dark counts and eliminatethe strong photosensitizer luminescence background.Singlet oxygen luminescence detection at 1270 nm is con-firmed through spectral filtering and lifetime fitting forRose Bengal in water, and Photofrin in methanol as mod-el photosensitizers. The overall performance, measuredby the signal-to-noise ratio, improves by a factor of 50over a previous system that used a fiberoptic-coupledsuperconducting nanowire single-photon detector. Theeffect of adding light scattering to the photosensitizer isalso examined as a first step towards applications in tissuein vivo.
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Publication status
- Published
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- Published version
Journal
Journal of BiophotonicsISSN
1864063XPublisher
Wiley-VCH VerlagExternal DOI
Issue
2Volume
10Page range
320-326Department affiliated with
- Engineering and Design Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-05-30First Open Access (FOA) Date
2018-05-31First Compliant Deposit (FCD) Date
2018-05-31Usage metrics
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