A compact fiber-optic probe-based singlet oxygen luminescence detection system

Gemmell, Nathan, McCarthy, Aongus, Kim, Michele M, Veilleux, Israel, Zhu, Timothy C, Buller, Gerald S, Wilson, Brian C and Hadfield, Robert H (2016) A compact fiber-optic probe-based singlet oxygen luminescence detection system. Journal of Biophotonics, 10 (2). pp. 320-326. ISSN 1864063X

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

This paper presents a novel compact fiberoptic basedsinglet oxygen near-infrared luminescence probe coupledto an InGaAs/InP single photon avalanche diode (SPAD)detector. Patterned time gating of the single-photon de-tector is used to limit unwanted dark counts and eliminatethe strong photosensitizer luminescence background.Singlet oxygen luminescence detection at 1270 nm is con-firmed through spectral filtering and lifetime fitting forRose Bengal in water, and Photofrin in methanol as mod-el photosensitizers. The overall performance, measuredby the signal-to-noise ratio, improves by a factor of 50over a previous system that used a fiberoptic-coupledsuperconducting nanowire single-photon detector. Theeffect of adding light scattering to the photosensitizer isalso examined as a first step towards applications in tissuein vivo.

Item Type: Article
Schools and Departments: School of Engineering and Informatics > Engineering and Design
Subjects: Q Science > QC Physics > QC0350 Optics. Light
Depositing User: Nathan Gemmell
Date Deposited: 30 May 2018 14:48
Last Modified: 02 Jul 2019 15:35
URI: http://sro.sussex.ac.uk/id/eprint/76238

View download statistics for this item

📧 Request an update