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Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector

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posted on 2023-06-09, 13:34 authored by Nathan R Gemmell, Aongus McCarthy, Baochang Liu, Michael G Tanner, Sander D Dorenbos, Valery Zwiller, Michael S Patterson, Gerald S Buller, Brian C Wilson, Robert H Hadfield
Direct monitoring of singlet oxygen (1O2) luminescence is a particularly challenging infrared photodetection problem. 1O2, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record 1O2 luminescence at 1270 nm wavelength from a model photosensitizer (Rose Bengal) in solution. Narrow band spectral filtering and chemical quenching is used to verify the 1O2 signal, and lifetime evolution with the addition of protein is studied. Furthermore, we demonstrate the detection of 1O2 luminescence through a single optical fiber, a marked advance for dose monitoring in clinical treatments such as photodynamic therapy.

History

Publication status

  • Published

File Version

  • Published version

Journal

Optics Express

ISSN

1094-4087

Publisher

Optical Society of America

Issue

4

Volume

21

Page range

5005

Department affiliated with

  • Engineering and Design Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-05-30

First Open Access (FOA) Date

2018-05-31

First Compliant Deposit (FCD) Date

2018-05-31

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