Lupo et al. 2018_Revised.doc_.pdf (467.99 kB)
Development of a psychiatric disorder linked to cerebellar lesions
journal contribution
posted on 2023-06-09, 13:14 authored by Michela Lupo, Giusy Olivito, Libera Siciliano, Marcella Masciullo, Marco Bozzali, Marco Molinari, Maria LeggioCerebellar dysfunction plays a critical role in neurodevelopmental disorders with long-term behavioral and neuropsychiatric symptoms. A 43-year-old woman with a cerebellum arteriovenous malformation and history of behavioral dysregulation since childhood is described. After the rupture of the cerebellar malformation in adulthood, her behavior morphed into specific psychiatric symptoms and cognitive deficits occurred. The neuropsychological assessment evidenced impaired performance in attention, visuospatial, memory, and language domains. Moreover, psychiatric assessment indicated a borderline personality disorder. Brain MRI examination detected macroscopic abnormalities in the cerebellar posterior lobules VI, VIIa (Crus I), and IX, and in the posterior area of the vermis, regions usually involved in cognitive and emotional processing. The described patient suffered from cognitive and behavioral symptoms that are part of the cerebellar cognitive affective syndrome. This case supports the hypothesis of a cerebellar role in personality disorders emphasizing the importance of also examining the cerebellum in the presence of behavioral disturbances in children and adults.
History
Publication status
- Published
File Version
- Accepted version
Journal
CerebellumISSN
1473-4230Publisher
Springer VerlagExternal DOI
Issue
465632Volume
17Page range
438-446Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-06-13First Open Access (FOA) Date
2019-02-19First Compliant Deposit (FCD) Date
2018-06-13Usage metrics
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