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Factors affecting the nuclear localization of ß-catenin in normal and malignant tissue
journal contribution
posted on 2023-06-09, 13:12 authored by Rhys MorganRhys Morgan, Jenna Ridsdale, Alex Tonks, Richard L DarleyThe canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been directed towards the aberrant expression and/or activity of the central mediator of this pathway, ß-catenin. In particular, the nuclear localization of ß-catenin and subsequent inappropriate activation of TCF/LEF-mediated transcription appears to be an important process in both the establishment and maintenance of cancer stem cells. Despite this, the exact mechanisms controlling ß-catenin nuclear localization in both normal and malignant cells are poorly understood. This prospect article brings together the many mechanisms previously reported to regulate the nuclear localization of ß-catenin and how they are relevant to cancer.
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Publication status
- Published
File Version
- Published version
Journal
Journal of Cellular BiochemistryISSN
0730-2312Publisher
John Wiley & SonsExternal DOI
Issue
8Volume
115Page range
1351-1361Department affiliated with
- Biochemistry Publications
Research groups affiliated with
- Haematology Research Group Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2018-05-10First Compliant Deposit (FCD) Date
2018-05-09Usage metrics
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