Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children

Turner, Steve, Francis, Ben, Wani, Nuha, Vijverberg, Susanne, Pino-Yanes, Maria, Mukhopadhyay, Somnath, Tavendale, Roger, Palmer, Colin, Burchard, Esteban G, Kebede Merid, Simon, Melen, Erik, Maitland-van der Zee, Anke H and Pharmacogenomics in Childhood Asthma Consortium, (2018) Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children. Pharmacogenomics, 19 (8). ISSN 1462-2416

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Abstract

Our hypothesis was that children with mutations in genes coding for Glutathione S-transferases (GST) have worse asthma outcomes compared to children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were non-significant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RJ Pediatrics > RJ0047.3 Genetic aspects
R Medicine > RJ Pediatrics > RJ0101 Child health. Child health services
Depositing User: Katie Isaac
Date Deposited: 03 May 2018 12:32
Last Modified: 01 Jul 2019 14:45
URI: http://sro.sussex.ac.uk/id/eprint/75598

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