Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Horsburgh, Karen, Wardlaw, Joanna M, van Agtmael, Tom, Allan, Stuart, Ashford, Mike L J, Bath, Philip M, Brown, Rosalind, Berwick, Jason, Cader, M Zameel, O Carare, Roxana, Davies, John B, Duncombe, Jessica, Farr, Tracy D, Fowler, Jill H, Goense, Jozien, Granata, Alessandra, Hall, Catherine and et al, (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132 (8). pp. 851-868. ISSN 0143-5221

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Cerebral small vessel disease (SVD) is a major health challenge. Therapeutic approaches remain limited, hampered by the lack of mechanistic understanding and identification of therapeutic targets. Relevant animal models could provide a cornerstone to basic scientific studies of disease mechanisms and pre-clinical studies of potential therapies, but there is a critical need to improve the current translational gap that exists between pre-clinical research and treatments in patients. The Medical Research Council Dementias Platform UK (MRC DPUK) Vascular Experimental Medicine Theme identified that a comprehensive assessment of the latest developments in animal models and of their contribution to understanding of cerebral microvascular disease would reduce the translational gap. In response to this, a two day workshop took place in late January 2017 at the British Heart Foundation Centre of Research Excellence in Glasgow, Scotland in conjunction with MRC DPUK and brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. There were presentations from UK and international researchers and a specific focus on animal models of cerebral microvascular disease and dementia, considering vascular biology, neurogliovascular coupling, blood-brain barrier function, neuroinflammation, cerebral drainage pathways, and methodological and translational challenges (see Figure 1 for the general organisation of the meeting including the key topics and themes discussed). This overview provides a summary of the key talks, with a particular focus on mechanisms of cerebral vascular disease (see Figure 2) and improving translation. These talks were followed by related themed discussion groups on the gaps in knowledge and requirements to advance knowledge, the outcomes of which are highlighted in Table 1. Additional related articles are published in the Special Edition of Clinical Science (

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Depositing User: Ellena Adams
Date Deposited: 23 Apr 2018 10:44
Last Modified: 01 Jul 2019 15:46

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