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Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study
journal contribution
posted on 2023-06-07, 16:16 authored by Valerie JenkinsValerie Jenkins, Valerie ShillingValerie Shilling, Lesley Fallowfield, Anthony Howell, Sam HuttonThis pilot study examines whether hormone therapy for breast cancer affects cognition. Patients participating in a randomised trial of anastrozole, tamoxifen alone or combined (ATAC) (n=94) and a group of women without breast cancer (n=35) completed a battery of neuropsychological measures. Compared with the control group, the patients were impaired on a processing speed task (p=0.032) and on a measure of immediate verbal memory (p=0.026) after controlling for the use of hormone replacement therapy in both groups. Patient group performance was not significantly related to length of treatment or measures of psychological morbidity. The results showed specific impairments in processing speed and verbal memory in women receiving hormonal therapy for the treatment of breast cancer. Verbal memory may be especially sensitive to changes in oestrogen levels, a finding commonly reported in studies of hormone replacement therapy in healthy women. In view of the increased use of hormone therapies in an adjuvant and preventative setting their impact on cognitive functioning should be investigated more thoroughly.
History
Publication status
- Published
Journal
Psycho-OncologyISSN
1057-9249Publisher
John Wiley & SonsExternal DOI
Issue
1Volume
13Page range
61-66Department affiliated with
- Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-04-23Usage metrics
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