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Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial
journal contribution
posted on 2023-06-09, 12:41 authored by J C Strefford, L Kadalayil, J Forster, M J J Rose-Zerilli, A Parker, T T Lin, N Heppel, K Norris, A Gardiner, Z Davies, D Gonzalez de Castro, M Else, A J Steele, H Parker, T Stankovic, Christopher PepperChristopher Pepper, C Fegan, D Baird, A Collins, D Catovsky, D G OscierTelomere erosion and fusion play an important role in the pathology of many common human malignancies including CLL.1,2 Previous studies in CLL have shown that short telomeres defined on the basis of the median value or receiver operating characteristic (ROC) analysis are associated with unmutated IGHV genes, poor risk genomic abnormalities, genomic complexity and high expression of CD38, CD49d, and ZAP70 whereas long telomeres are associated with increasing IGHV mutational load, isolated deletion of 13q and low CD49d expression. In addition, in predominantly diagnostic or mixed patient cohorts, telomere length (TL) predicts time to first treatment and/or overall survival (OS) in multivariate analyses of models incorporating established biomarkers. 3-7 However uncertainties about the most clinically relevant measure of telomere length, the optimal choice of assay, the need for assay standardisation and the lack of published data on the prognostic value of TL in patients entered into randomised trials have hindered the implementation of TL measurement into routine clinical practice. We have attempted to address these issues by measuring telomere length using monochrome multiplex Q-PCR (MMQ-PCR) in 384 patients at randomisation into the UK LRF CLL4 phase 3 chemotherapy trial (Table S1), of whom 111 samples were also screened by single telomere
History
Publication status
- Published
File Version
- Accepted version
Journal
LeukemiaISSN
0887-6924Publisher
Nature Publishing GroupExternal DOI
Issue
12Volume
29Page range
2411-2414Department affiliated with
- Clinical and Experimental Medicine Publications
Research groups affiliated with
- Haematology Research Group Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-04-04First Open Access (FOA) Date
2018-04-04First Compliant Deposit (FCD) Date
2018-04-04Usage metrics
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