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Integrating DNA damage repair with the cell cycle

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journal contribution
posted on 2023-06-09, 12:36 authored by Jo Murray, Antony CarrAntony Carr
Abstract DNA is labile and constantly subject to damage. In addition to external mutagens, DNA is continuously damaged by the aqueous environment, cellular metabolites and is prone to strand breakage during replication. Cell duplication is orchestrated by the cell division cycle and specific DNA structures are processed differently depending on where in the cell cycle they are detected. This is often because a specific structure is physiological in one context, for example during DNA replication, while indicating a potentially pathological event in another, such as interphase or mitosis. Thus, contextualising the biochemical entity with respect to cell cycle progression provides information necessary to appropriately regulate DNA processing activities. We review the links between DNA repair and cell cycle context, drawing together recent advances.

Funding

Replication arrest, restart and genome instability; G1829; WELLCOME TRUST; 110047/Z/15/Z

How do Smc5/6 interactions with DNA coordinate replication and recombination?; G2119; MRC-MEDICAL RESEARCH COUNCIL; MR/P018955/1

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Current Opinion in Cell Biology

ISSN

0955-0674

Publisher

Elsevier

Volume

52

Page range

120-125

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Research groups affiliated with

  • Genome Damage and Stability Centre Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-03-23

First Open Access (FOA) Date

2019-03-26

First Compliant Deposit (FCD) Date

2019-03-26

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