Neurosyphilis in HIV 18.1.pdf (365.15 kB)
Neurosyphilis in patients with HIV
journal contribution
posted on 2023-06-09, 12:32 authored by Emily Hobbs, Jaime Vera RojasJaime Vera Rojas, Michael Marks, Andrew BarrittAndrew Barritt, Basil H Ridha, David LawrenceSyphilis is a resurgent sexually transmitted infection in the UK that is disproportionately diagnosed in patients living with HIV, particularly in men who have sex with men. Syphilis appears to present differently in patients with HIV, particularly in those with severe immunosuppression. Progression to neurosyphilis is more common in HIV coinfection and can be asymptomatic, often for several years. The presentations of neurosyphilis vary but can include meningitis, meningovascular disease, general paresis and tabes dorsalis. There is debate about the circumstances in which to perform a lumbar puncture, and the current gold standard diagnostics have inadequate sensitivity. We recommend a pragmatic approach to lumbar punctures, interpreting investigations and deciding when to consider treatment with a neuropenetrative antibiotic regimen.
History
Publication status
- Published
File Version
- Accepted version
Journal
Practical NeurologyISSN
1474-7758Publisher
BMJ Publishing GroupExternal DOI
Issue
3Volume
18Page range
211-218Department affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-03-20First Open Access (FOA) Date
2019-02-24First Compliant Deposit (FCD) Date
2018-03-20Usage metrics
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