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Neurosyphilis in HIV 18.1.pdf (365.15 kB)

Neurosyphilis in patients with HIV

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posted on 2023-06-09, 12:32 authored by Emily Hobbs, Jaime Vera RojasJaime Vera Rojas, Michael Marks, Andrew BarrittAndrew Barritt, Basil H Ridha, David Lawrence
Syphilis is a resurgent sexually transmitted infection in the UK that is disproportionately diagnosed in patients living with HIV, particularly in men who have sex with men. Syphilis appears to present differently in patients with HIV, particularly in those with severe immunosuppression. Progression to neurosyphilis is more common in HIV coinfection and can be asymptomatic, often for several years. The presentations of neurosyphilis vary but can include meningitis, meningovascular disease, general paresis and tabes dorsalis. There is debate about the circumstances in which to perform a lumbar puncture, and the current gold standard diagnostics have inadequate sensitivity. We recommend a pragmatic approach to lumbar punctures, interpreting investigations and deciding when to consider treatment with a neuropenetrative antibiotic regimen.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Practical Neurology

ISSN

1474-7758

Publisher

BMJ Publishing Group

Issue

3

Volume

18

Page range

211-218

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-03-20

First Open Access (FOA) Date

2019-02-24

First Compliant Deposit (FCD) Date

2018-03-20

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