Erratum: Interneuronal mechanism for Tinbergen's hierarchical model of behavioral choice

Pirger, Zsolt, Crossley, Michael, Laszlo, Zita, Naskar, Souvik, Kemenes, George, O'Shea, Michael, Benjamin, Paul and Kemenes, Ildiko (2014) Erratum: Interneuronal mechanism for Tinbergen's hierarchical model of behavioral choice. Current Biology, 24 (18). pp. 2018-2024. ISSN 0960-9822

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Recent studies of behavioral choice support the notion that the decision to carry out one behavior rather than another depends on the reconfiguration of shared interneuronal networks [1]. We investigated another decision-making strategy, derived from the classical ethological literature [2, 3], which proposes that behavioral choice depends on competition between autonomous networks. According to this model, behavioral choice depends on inhibitory interactions between incompatible hierarchically organized behaviors. We provide evidence for this by investigating the interneuronal mechanisms mediating behavioral choice between two autonomous circuits that underlie whole-body withdrawal [4, 5] and feeding [6] in the pond snail Lymnaea. Whole-body withdrawal is a defensive reflex that is initiated by tactile contact with predators. As predicted by the hierarchical model, tactile stimuli that evoke whole-body withdrawal responses also inhibit ongoing feeding in the presence of feeding stimuli. By recording neurons from the feeding and withdrawal networks, we found no direct synaptic connections between the interneuronal and motoneuronal elements that generate the two behaviors. Instead, we discovered that behavioral choice depends on the interaction between two unique types of interneurons with asymmetrical synaptic connectivity that allows withdrawal to override feeding. One type of interneuron, the Pleuro-Buccal (PlB), is an extrinsic modulatory neuron of the feeding network that completely inhibits feeding when excited by touch-induced monosynaptic input from the second type of interneuron, Pedal-Dorsal12 (PeD12). PeD12 plays a critical role in behavioral choice by providing a synaptic pathway joining the two behavioral networks that underlies the competitive dominance of whole-body withdrawal over feeding.

Item Type: Article
Additional Information: Original version:
Keywords: Behavioral choice, mutually exclusive behaviors, hierarchical organization, feeding, whole-body withdrawal, interneurons, asymmetrical connectivity
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Learning, Memory and Plasticity Group
Related URLs:
Depositing User: Ildiko Kemenes
Date Deposited: 05 Mar 2018 14:13
Last Modified: 02 Jul 2019 16:18

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Project NameSussex Project NumberFunderFunder Ref
Decision Making in Neural Networks: Influence of LearningG0189BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBB/H009906/1
Lapses in memory: opportunities for adaptive behaviourG1199BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCILBB/K018515/1