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Disruption of semantic metwork in mild Alzheimer's disease revealed by resting-state fMRI

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posted on 2023-06-09, 12:17 authored by Daniele Mascali, Mauro DiNuzzo, Laura Serra, Silvia Mangia, Bruno Maraviglia, Marco Bozzali, Federico Giove
Subtle semantic deficits can be observed in Alzheimer's disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-state functional magnetic resonance imaging in a cohort of patients with mild AD (n?=?38; mean mini-mental state examination?=?20.5) and in a group of age-matched healthy controls (n?=?19). Voxel-wise analysis spatially constrained in the left fronto-temporal semantic control network identified two regions with altered functional connectivity (FC) in AD patients, specifically in the pars opercularis (POp, BA44) and in the posterior middle temporal gyrus (pMTG, BA21). Using whole-brain seed-based analysis, we demonstrated that these two regions have altered FC even beyond the semantic control network. In particular, the pMTG displayed a wide-distributed pattern of lower connectivity to several brain regions involved in language-semantic processing, along with a possibly compensatory higher connectivity to the Wernicke's area. We conclude that in mild AD brain regions belonging to the semantic control network are abnormally connected not only within the network, but also to other areas known to be critical for language processing.

History

Publication status

  • Published

File Version

  • Published version

Journal

Neuroscience

ISSN

1873-7544

Publisher

Elsevier

Volume

371

Page range

38-48

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-02-21

First Open Access (FOA) Date

2018-02-21

First Compliant Deposit (FCD) Date

2018-02-21

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