University of Sussex
Browse
Lancaster, Claire.pdf (12.59 MB)

Apolipoprotein e4 and attentional control: understanding the trajectory of cognitive ageing from mid-life

Download (12.59 MB)
thesis
posted on 2023-06-09, 12:05 authored by Claire LancasterClaire Lancaster
The greatest genetic factor in how well we age cognitively is Apolipoprotein E (APOE), a single nucleotide polymorphism with three allelic variants: epsilon-2, epsilon-3 and epsilon-4 (hereafter e2, e3, e4). The e4 allele is associated with an increased risk of cognitive disadvantage in later life, however, the effects of this variant are not isolated to old-age, with some studies reporting cognitive advantages in youth. This thesis investigates the influence of APOE e4 on cognition from mid-adulthood, a point in the lifespan when the detrimental effects of this allele may be emerging. This thesis begins with a systematic review and meta-analysis of the literature to-date, and suggests attention may be sensitive to e4 differences in mid-adulthood, however, effects of the allele are not consistently shown, perhaps due to methodological limitations including the use of insensitive neuropsychological batteries (Chapter 1). Next, behavioural paradigms providing a sensitive index of both selective (Chapter 2) and executive attention (Chapter 3), suggest many attentional processes are intact in mid-age (45-55 years) e4 carriers. Subtle deficits, however, are apparent on prospective memory (PM) and Stroop-switch paradigms, indicating a goal maintenance disadvantage. In addition, a proxy of cognitive reserve was found to moderate the effects of e4 on executive attention in mid-adulthood (Chapter 4). Follow-up research used paradigms that target the distinct processes supporting focal and non-focal PM to interrogate the profile of change observed in mid-age e4 carriers, identifying a profile of disadvantage consistent with that observed in pathological ageing (Chapter 5). PM, however, was not found to differentiate e4 carriers in older individuals at heightened risk of converting to dementia (Chapter 6). Collectively, this research provides evidence for a profile of accelerated ageing in e4 carriers, with subtle disadvantages apparent in executive attention by the end of the 5th decade.

History

File Version

  • Published version

Pages

201.0

Department affiliated with

  • Psychology Theses

Qualification level

  • doctoral

Qualification name

  • phd

Language

  • eng

Institution

University of Sussex

Full text available

  • Yes

Legacy Posted Date

2018-02-13

Usage metrics

    University of Sussex (Theses)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC