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Understanding miro GTPases: implications in the treatment of neurodegenerative disorders

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posted on 2023-06-09, 11:56 authored by Laura Kay, Ilse Pienaar, Ruwini Cooray, Meera Soundararajan
The Miro GTPases represent an unusual subgroup of the Ras superfamily and have recently emerged as important mediators of mitochondrial dynamics and for maintaining neuronal health. It is now well-established that these enzymes act as essential components of a Ca2+-sensitive motor complex, facilitating the transport of mitochondria along microtubules in several cell types, including dopaminergic neurons. The Miros appear to be critical for both anterograde and retrograde mitochondrial transport in axons and dendrites, both of which are considered essential for neuronal health. Furthermore, the Miros may be significantly involved in the development of several serious pathological processes, including the development of neurodegen- erative and psychiatric disorders. In this review, we discuss the molecular structure and known mitochondrial functions of the Miro GTPases in humans and other organisms, in the context of neurodegenerative disease. Finally, we consider the potential human Miros hold as novel therapeutic targets for the treatment of such disease.

History

Publication status

  • Published

File Version

  • Published version

Journal

Molecular Neurobiology

ISSN

0893-7648

Publisher

Springer

Issue

9

Volume

55

Page range

7352-7365

Department affiliated with

  • Biology and Environmental Science Publications

Notes

Laura Kay and Ilse S. Pienaar contributed equally to this work (joint first-authors)

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-02-06

First Open Access (FOA) Date

2018-02-06

First Compliant Deposit (FCD) Date

2018-02-06

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