Comparison between early-onset and late-onset alzheimer's disease patients with amnestic presentation: CSF and 18F-FDG PET study

Chiaravalloti, Agostino, Koch, Giacomo, Toniolo, Sofia, Belli, Lorena, Lorenzo, Francesco Di, Gaudenzi, Sara, Schillaci, Orazio, Bozzali, Marco, Sancesario, Giuseppe and Martorana, Alessandro (2016) Comparison between early-onset and late-onset alzheimer's disease patients with amnestic presentation: CSF and 18F-FDG PET study. Dementia and geriatric cognitive disorders extra, 6 (1). pp. 108-119. ISSN 1664-5464

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Abstract

BACKGROUND/AIMS

To investigate the differences in brain glucose consumption between patients with early onset of Alzheimer's disease (EOAD, aged ≤65 years) and patients with late onset of Alzheimer's disease (LOAD, aged >65 years).

METHODS
Differences in brain glucose consumption between the groups have been evaluated by means of Statistical Parametric Mapping version 8, with the use of age, sex, Mini-Mental State Examination and cerebrospinal fluid values of AΒ1-42, phosphorylated Tau and total Tau as covariates in the comparison between EOAD and LOAD.

RESULTS
As compared to LOAD, EOAD patients showed a significant decrease in glucose consumption in a wide portion of the left parietal lobe (BA7, BA31 and BA40). No significant differences were obtained when subtracting the EOAD from the LOAD group.

CONCLUSIONS
The results of our study show that patients with EOAD show a different metabolic pattern as compared to those with LOAD that mainly involves the left parietal lobe.

Item Type: Article
Keywords: Alzheimer's disease; Cerebrospinal fluid biomarkers; Early onset; Late onset; Precuneus
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 06 Dec 2019 12:46
Last Modified: 06 Dec 2019 12:46
URI: http://sro.sussex.ac.uk/id/eprint/72905

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