Comparison between Early-Onset and Late-Onset Alzheimers Disease Patients with Amnestic Presentation - CSF and 18F-FDG PET Study.pdf (1.32 MB)
Comparison between early-onset and late-onset alzheimer's disease patients with amnestic presentation: CSF and 18F-FDG PET study
journal contribution
posted on 2023-06-09, 11:39 authored by Agostino Chiaravalloti, Giacomo Koch, Sofia Toniolo, Lorena Belli, Francesco Di Lorenzo, Sara Gaudenzi, Orazio Schillaci, Marco Bozzali, Giuseppe Sancesario, Alessandro MartoranaBACKGROUND/AIMS To investigate the differences in brain glucose consumption between patients with early onset of Alzheimer's disease (EOAD, aged =65 years) and patients with late onset of Alzheimer's disease (LOAD, aged >65 years). METHODS Differences in brain glucose consumption between the groups have been evaluated by means of Statistical Parametric Mapping version 8, with the use of age, sex, Mini-Mental State Examination and cerebrospinal fluid values of A?1-42, phosphorylated Tau and total Tau as covariates in the comparison between EOAD and LOAD. RESULTS As compared to LOAD, EOAD patients showed a significant decrease in glucose consumption in a wide portion of the left parietal lobe (BA7, BA31 and BA40). No significant differences were obtained when subtracting the EOAD from the LOAD group. CONCLUSIONS The results of our study show that patients with EOAD show a different metabolic pattern as compared to those with LOAD that mainly involves the left parietal lobe.
History
Publication status
- Published
File Version
- Published version
Journal
Dementia and geriatric cognitive disorders extraISSN
1664-5464Publisher
Karger Publishers Open AccessExternal DOI
Issue
1Volume
6Page range
108-119Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-12-06First Open Access (FOA) Date
2019-12-06First Compliant Deposit (FCD) Date
2019-12-06Usage metrics
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