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Comparison between Early-Onset and Late-Onset Alzheimers Disease Patients with Amnestic Presentation - CSF and 18F-FDG PET Study.pdf (1.32 MB)

Comparison between early-onset and late-onset alzheimer's disease patients with amnestic presentation: CSF and 18F-FDG PET study

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posted on 2023-06-09, 11:39 authored by Agostino Chiaravalloti, Giacomo Koch, Sofia Toniolo, Lorena Belli, Francesco Di Lorenzo, Sara Gaudenzi, Orazio Schillaci, Marco Bozzali, Giuseppe Sancesario, Alessandro Martorana
BACKGROUND/AIMS To investigate the differences in brain glucose consumption between patients with early onset of Alzheimer's disease (EOAD, aged =65 years) and patients with late onset of Alzheimer's disease (LOAD, aged >65 years). METHODS Differences in brain glucose consumption between the groups have been evaluated by means of Statistical Parametric Mapping version 8, with the use of age, sex, Mini-Mental State Examination and cerebrospinal fluid values of A?1-42, phosphorylated Tau and total Tau as covariates in the comparison between EOAD and LOAD. RESULTS As compared to LOAD, EOAD patients showed a significant decrease in glucose consumption in a wide portion of the left parietal lobe (BA7, BA31 and BA40). No significant differences were obtained when subtracting the EOAD from the LOAD group. CONCLUSIONS The results of our study show that patients with EOAD show a different metabolic pattern as compared to those with LOAD that mainly involves the left parietal lobe.

History

Publication status

  • Published

File Version

  • Published version

Journal

Dementia and geriatric cognitive disorders extra

ISSN

1664-5464

Publisher

Karger Publishers Open Access

Issue

1

Volume

6

Page range

108-119

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-12-06

First Open Access (FOA) Date

2019-12-06

First Compliant Deposit (FCD) Date

2019-12-06

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