CSF β-amyloid as a putative biomarker of disease progression in multiple sclerosis

Pietroboni, Anna M, Schiano di Cola, Francesca, Scarioni, Marta, Fenoglio, Chiara, Spanò, Barbara, Arighi, Andrea, Cioffi, Sara M G, Oldoni, Emanuela, De Riz, Milena A, Basilico, Paola, Calvi, Alberto, Fumagalli, Giorgio G, Triulzi, Fabio, Galimberti, Daniela, Bozzali, Marco and Scarpini, Elio (2017) CSF β-amyloid as a putative biomarker of disease progression in multiple sclerosis. Multiple Sclerosis, 23 (8). pp. 1085-1091. ISSN 1477-0970

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Abstract

BACKGROUND
Neurodegeneration plays a major role in determining disability in multiple sclerosis (MS) patients. Hence, there is increasing need to identify reliable biomarkers, which could serve as prognostic measure of disease progression.

OBJECTIVES
To assess whether cerebrospinal fluid (CSF) tau and β-amyloid (Aβ) levels were altered in newly diagnosed MS patients and correlated with disability. Moreover, we investigated whether these CSF biomarkers associate with macroscopic brain tissue damage measures.

METHODS
CSF Aβ and tau levels were determined by enzyme-linked immunosorbent assay in CSF samples from 48 newly diagnosed MS patients, followed-up clinically for 3 years by recording their Expanded Disability Status Scale score at 6-month intervals, and 45 controls. All patients underwent magnetic resonance imaging at baseline and at the end of follow-up to quantify their lesion load (LL).

RESULTS
CSF Aβ levels were significantly reduced in patients compared to controls ( p < 0.001). Lower CSF Aβ levels at baseline were a disability predictor at 3-year follow-up ( p = 0.009). CSF tau levels correlated with T2- and T1-LL ( p < 0.001).

CONCLUSION
CSF Aβ reduction is a promising biomarker of neurodegeneration and may predict patients' clinical outcome. Therefore, CSF Aβ should be considered as a potential biomarker of prognostic value.

Item Type: Article
Keywords: Multiple sclerosis, neurodegeneration, biomarker, beta-amyloid, tau
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 06 Dec 2019 12:51
Last Modified: 06 Dec 2019 12:51
URI: http://sro.sussex.ac.uk/id/eprint/72902
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