Hierarchical coding for sequential task events in the monkey prefrontal cortex

Sigala, Natasha, Kusunoki, Makoto, Nimmo-Smith, Ian, Gaffan, David and Duncan, John (2008) Hierarchical coding for sequential task events in the monkey prefrontal cortex. Proceedings of the National Academy of Sciences, 105 (33). pp. 11969-11974. ISSN 0027-8424

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The frontal lobes play a key role in sequential organization of behavior. Little is known, however, of the way frontal neurons code successive phases of a structured task plan. Using correlational analysis, we asked how a population of frontal cells represents the multiple events of a complex sequential task. Monkeys performed a conventional cue-target association task, with distinct cue, delay, and target phases. Across the population of recorded cells, we examined patterns of activity for different task phases, and in the same phase, for different stimulus objects. The results show hierarchical representation of task events. For different task phases, there were different, approximately orthogonal patterns of activity across the population. of neurons. Modulations of each basic pattern encoded stimulus information within each phase. By orthogonal coding, the frontal lobe may control transitions between the discrete steps of a mental program; by correlated coding within each step, similar operations may be applied to different stimulus content

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
T Technology > T Technology (General)
Depositing User: Grecia GarciaGarcia
Date Deposited: 22 Aug 2011 10:29
Last Modified: 26 Sep 2017 11:56
URI: http://sro.sussex.ac.uk/id/eprint/7279
Google Scholar:26 Citations
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