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MPS and recurrence of depression and anxiety.pdf (476.37 kB)

Longitudinal associations of multiple physical symptoms with recurrence of depressive and anxiety disorders

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posted on 2023-06-09, 11:31 authored by Sandra M A Dijkstra-Kersten, Kate Sitnikova, Berend Terluin, Brenda W J H Penninx, Jos W R Twisk, Harm van MarwijkHarm van Marwijk, Henriette E van der Horst, Johannes C van der Wouden
Objective To examine longitudinal associations of multiple physical symptoms with recurrence of depressive and anxiety disorders. Methods Follow-up data of 584 participants with remitted depressive or anxiety disorders were used from the Netherlands Study of Depressive and Anxiety disorders. Multiple physical symptoms were measured at baseline (T1) and two-year follow-up (T2) by the Four-Dimensional Symptom Questionnaire (4DSQ) somatization subscale. Recurrence of depressive and anxiety disorders was assessed at two-year (T2) and four-year (T4) follow-up with the Composite International Diagnostic Interview. Logistic Generalized Estimating Equations were used to examine associations of multiple physical symptoms with recurrence of depressive and anxiety disorders. Depressive (IDS-SR) and anxiety symptoms (BAI), and other relevant covariates were taken into account. Results Multiple physical symptoms were significantly associated with recurrence of depression (OR = 1.04, 95%CI = 1.00–1.08), anxiety (OR = 1.07, 95%CI = 1.03–1.12), and depressive or anxiety disorders (OR = 1.06, 95%CI = 1.02–1.10), on average over time. Odds ratios did not change substantially when the IDS-SR mood-cognition and BAI subjective scale were included as covariates. Conclusion The presence of multiple physical symptoms was positively related to recurrence of depressive and anxiety disorders, independent of depressive and anxiety symptoms. Knowledge of risk factors for recurrence of depressive and anxiety disorders, such as the presence of multiple physical symptoms, could provide possibilities for better targeting interventions to prevent recurrence.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Psychosomatic Research

ISSN

0022-3999

Publisher

Elsevier

Volume

97

Page range

96-101

Department affiliated with

  • Primary Care and Public Health Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-01-12

First Open Access (FOA) Date

2018-04-24

First Compliant Deposit (FCD) Date

2018-01-24

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