Interoception and inflammation in psychiatric disorders.pdf (5.36 MB)
Interoception and inflammation in psychiatric disorders
journal contribution
posted on 2023-06-09, 09:38 authored by Jonathan Savitz, Neil HarrisonDespite a historical focus on neurally-mediated interoceptive signaling mechanisms, humoral (and even cellular) signals also play an important role in communicating bodily physiological state to the brain. These signaling pathways can perturb neuronal structure, chemistry and function leading to discrete changes in behavior. They are also increasingly implicated in the pathophysiology of psychiatric disorders. The importance of these humoral signaling pathways is perhaps most powerfully illustrated in the context of infection and inflammation. Here we provide an overview of how immune activation of neural and humoral interoceptive mechanisms interact to mediate discrete changes in brain and behavior and highlight how activation of these pathways at specific points in neural development may predispose to psychiatric disorder. As our mechanistic understanding of these interoceptive pathways continues to emerge it is revealing novel therapeutic targets, potentially heralding an exciting new era of immunotherapies in psychiatry.
Funding
Mechanisms of Human Sickness; G0043; WELLCOME TRUST; 093881/Z/10/Z
History
Publication status
- Published
File Version
- Accepted version
Journal
Biological Psychiatry: Cognitive Neuroscience and NeuroimagingISSN
2451-9022Publisher
ElsevierExternal DOI
Issue
6Volume
3Page range
514-524Department affiliated with
- BSMS Neuroscience Publications
Research groups affiliated with
- Sackler Centre for Consciousness Science Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-01-05First Open Access (FOA) Date
2019-01-09First Compliant Deposit (FCD) Date
2018-01-05Usage metrics
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