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Interoception and inflammation in psychiatric disorders.pdf (5.36 MB)

Interoception and inflammation in psychiatric disorders

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journal contribution
posted on 2023-06-09, 09:38 authored by Jonathan Savitz, Neil Harrison
Despite a historical focus on neurally-mediated interoceptive signaling mechanisms, humoral (and even cellular) signals also play an important role in communicating bodily physiological state to the brain. These signaling pathways can perturb neuronal structure, chemistry and function leading to discrete changes in behavior. They are also increasingly implicated in the pathophysiology of psychiatric disorders. The importance of these humoral signaling pathways is perhaps most powerfully illustrated in the context of infection and inflammation. Here we provide an overview of how immune activation of neural and humoral interoceptive mechanisms interact to mediate discrete changes in brain and behavior and highlight how activation of these pathways at specific points in neural development may predispose to psychiatric disorder. As our mechanistic understanding of these interoceptive pathways continues to emerge it is revealing novel therapeutic targets, potentially heralding an exciting new era of immunotherapies in psychiatry.

Funding

Mechanisms of Human Sickness; G0043; WELLCOME TRUST; 093881/Z/10/Z

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

ISSN

2451-9022

Publisher

Elsevier

Issue

6

Volume

3

Page range

514-524

Department affiliated with

  • BSMS Neuroscience Publications

Research groups affiliated with

  • Sackler Centre for Consciousness Science Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-01-05

First Open Access (FOA) Date

2019-01-09

First Compliant Deposit (FCD) Date

2018-01-05

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