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Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the Parkinsonian rat

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Version 2 2023-06-12, 08:48
Version 1 2023-06-09, 09:37
journal contribution
posted on 2023-06-12, 08:48 authored by Timothy O West, Luc BerthouzeLuc Berthouze, David M Halliday, Vladimir Litvak, Andrew Sharott, Peter J Magill, Simon F Farmer
Much of the motor impairment associated with Parkinson’s disease is thought to arise from pathological activity in the networks formed by the basal ganglia (BG) and motor cortex. To evaluate several hypotheses proposed to explain the emergence of pathological oscillations in Parkinsonism, we investigated changes to the directed connectivity in BG networks following dopamine depletion. We recorded local field potentials (LFPs) in the cortex and basal ganglia of rats rendered Parkinsonian by injection of 6-hydroxydopamine (6-OHDA) and in dopamine-intact controls. We performed systematic analyses of the networks using a novel tool for estimation of directed interactions (Non-Parametric Directionality, NPD). Additionally, we used a ‘conditioned’ version of the NPD analysis which reveals the dependence of the correlation between two signals upon a third reference signal. We find evidence of the dopamine dependency of both low beta (14-20 Hz) and high beta/low gamma (20-40 Hz) directed interactions within the network. Notably, 6-OHDA lesions were associated with enhancement of the cortical “hyper-direct” connection to the subthalamic nucleus (STN) and its feedback to the cortex and striatum. We find that pathological beta synchronization resulting from 6-OHDA lesioning is widely distributed across the network and cannot be located to any individual structure. Further, we provide evidence that high beta/gamma oscillations propagate through the striatum in a pathway that is independent of STN. Rhythms at high beta/gamma show susceptibility to conditioning that indicates a hierarchical organization when compared to low beta. These results further inform our understanding of the substrates for pathological rhythms in salient brain networks in Parkinsonism.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Neurophysiology

ISSN

0022-3077

Publisher

American Physical Society

Volume

119

Page range

1608-1628

Department affiliated with

  • Informatics Publications

Research groups affiliated with

  • Centre for Computational Neuroscience and Robotics Publications
  • Evolutionary and Adaptive Systems Research Group Publications
  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-01-19

First Open Access (FOA) Date

2018-07-03

First Compliant Deposit (FCD) Date

2018-01-19

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