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High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea and premenstrual syndrome in adolescents

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posted on 2023-06-21, 06:02 authored by A Bahrami, A Avan, HR Sadeghnia, H Esmaeili, M Tayefi, F Ghasemi, FN Salehkhani, M Arabpour-Dahoue, A Rastegar, Gordon FernsGordon Ferns, H Bahrami-Taghanaki, M Ghayour-Mobarhan
Vitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received 9 high-dose vitamin D supplements (as 50000 IU/ week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in 4 categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects. The prevalence of PMS after the intervention fell from 14.9% to 4.8% (P<0.001). Similar results were also found for the prevalence of subjects with dysmenorrhea (35.9% reduced to 32.4%), and in subjects with both PMS and dysmenorrhea (32.7% reduced 25.7%). Vitamin D supplementation was associated with a reduction in the incidence of several symptoms of PMS such as backache and tendency to cry easily as well decrement in pain severity of dysmenorrhea (P<0.05). High dose vitamin D supplementation can reduced the prevalence of PMS and dysmenorrhea as well has positive effects on the physical and psychological symptoms of PMS.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Gynecological Endocrinology

ISSN

1473-0766

Publisher

Taylor & Francis

Issue

8

Volume

34

Page range

659-663

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-01-02

First Open Access (FOA) Date

2019-02-15

First Compliant Deposit (FCD) Date

2017-12-31

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