HighdosevitaminDsupplementationcanimprovemenstrualproblem%20gf.pdf (670.09 kB)
High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea and premenstrual syndrome in adolescents
journal contribution
posted on 2023-06-21, 06:02 authored by A Bahrami, A Avan, HR Sadeghnia, H Esmaeili, M Tayefi, F Ghasemi, FN Salehkhani, M Arabpour-Dahoue, A Rastegar, Gordon FernsGordon Ferns, H Bahrami-Taghanaki, M Ghayour-MobarhanVitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received 9 high-dose vitamin D supplements (as 50000 IU/ week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in 4 categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects. The prevalence of PMS after the intervention fell from 14.9% to 4.8% (P<0.001). Similar results were also found for the prevalence of subjects with dysmenorrhea (35.9% reduced to 32.4%), and in subjects with both PMS and dysmenorrhea (32.7% reduced 25.7%). Vitamin D supplementation was associated with a reduction in the incidence of several symptoms of PMS such as backache and tendency to cry easily as well decrement in pain severity of dysmenorrhea (P<0.05). High dose vitamin D supplementation can reduced the prevalence of PMS and dysmenorrhea as well has positive effects on the physical and psychological symptoms of PMS.
History
Publication status
- Published
File Version
- Accepted version
Journal
Gynecological EndocrinologyISSN
1473-0766Publisher
Taylor & FrancisExternal DOI
Issue
8Volume
34Page range
659-663Department affiliated with
- Division of Medical Education Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-01-02First Open Access (FOA) Date
2019-02-15First Compliant Deposit (FCD) Date
2017-12-31Usage metrics
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