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Analysis of the uncertainty in microbubble characterization

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posted on 2023-06-09, 09:32 authored by Caroline Harfield, Christopher R Fury, Gianluca MemoliGianluca Memoli, Philip Jones, Nick Ovenden, Eleanor Stride
There is increasing interest in the use of microbubble contrast agents for quantitative imaging applications such as perfusion and blood pressure measurement. The response of a microbubble to ultrasound excitation is, however, extremely sensitive to its size, the properties of its coating and the characteristics of the sound field and surrounding environment. Hence the results of microbubble characterization experiments can be significantly affected by experimental uncertainties, and this can limit their utility in predictive modelling. The aim of this study was to attempt to quantify these uncertainties and their influence upon measured microbubble characteristics. Estimates for the parameters characterizing the microbubble coating were obtained by fitting model data to numerical simulations of microbubble dynamics. The effect of uncertainty in different experimental parameters was gauged by modifying the relevant input values to the fitting process. The results indicate that even the minimum expected uncertainty in, for example, measurements of microbubble radius using conventional optical microscopy, leads to variations in the estimated coating parameters of ~20%. This should be taken into account in designing microbubble characterization experiments and in the use of data obtained from them.

History

Publication status

  • Published

File Version

  • Published version

Journal

Ultrasound in Medicine & Biology

ISSN

0301-5629

Publisher

Elsevier

Issue

6

Volume

42

Page range

1412 - 1418

Department affiliated with

  • Informatics Publications

Research groups affiliated with

  • Creative Technology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-01-02

First Open Access (FOA) Date

2018-01-02

First Compliant Deposit (FCD) Date

2018-01-02

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