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Analysis of the uncertainty in microbubble characterization
journal contribution
posted on 2023-06-09, 09:32 authored by Caroline Harfield, Christopher R Fury, Gianluca MemoliGianluca Memoli, Philip Jones, Nick Ovenden, Eleanor StrideThere is increasing interest in the use of microbubble contrast agents for quantitative imaging applications such as perfusion and blood pressure measurement. The response of a microbubble to ultrasound excitation is, however, extremely sensitive to its size, the properties of its coating and the characteristics of the sound field and surrounding environment. Hence the results of microbubble characterization experiments can be significantly affected by experimental uncertainties, and this can limit their utility in predictive modelling. The aim of this study was to attempt to quantify these uncertainties and their influence upon measured microbubble characteristics. Estimates for the parameters characterizing the microbubble coating were obtained by fitting model data to numerical simulations of microbubble dynamics. The effect of uncertainty in different experimental parameters was gauged by modifying the relevant input values to the fitting process. The results indicate that even the minimum expected uncertainty in, for example, measurements of microbubble radius using conventional optical microscopy, leads to variations in the estimated coating parameters of ~20%. This should be taken into account in designing microbubble characterization experiments and in the use of data obtained from them.
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Publication status
- Published
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- Published version
Journal
Ultrasound in Medicine & BiologyISSN
0301-5629Publisher
ElsevierIssue
6Volume
42Page range
1412 - 1418Department affiliated with
- Informatics Publications
Research groups affiliated with
- Creative Technology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-01-02First Open Access (FOA) Date
2018-01-02First Compliant Deposit (FCD) Date
2018-01-02Usage metrics
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