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Streitz, Mathias, Fuhrmann, Stephan, Powell, Fiona, Quassem, Ali, Nomura, Laurel, Maecker, Holden, Martus, Peter, Volk, Hans-Dieter and Kern, Florian (2011) Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination. Journal of Infectious Diseases, 203 (3). pp. 378-382. ISSN 0022-1899
Full text not available from this repository.Abstract
Functional characteristics of tuberculosis (TB)-specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon gamma [IFN-gamma], tumor necrosis factor alpha [TNF-alpha], and interleukin 2 [IL-2\ production). Interestingly, CD154 up-regulation accounted for similar to 80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-gamma accounted for only similar to 50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-gamma production alone.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine |
| Subjects: | Q Science > QR Microbiology Q Science > QR Microbiology > QR0180 Immunology R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases |
| Depositing User: | Grecia GarciaGarcia |
| Date Deposited: | 17 Aug 2011 10:30 |
| Last Modified: | 03 Jul 2012 14:27 |
| URI: | http://sro.sussex.ac.uk/id/eprint/7241 |
| Google Scholar: | 3 Citations |